Anti-SPIN2B Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

SPIN2B

Immunogen :

Recombinant protein of human SPIN2B

Synonym :

SPIN2B;SPIN-2;SPIN-2B;SPIN2_duplicate;TDRD26;dJ323P24.2;spindlin-2B

Isotype :

IgG

Gene ID :

474343

Clone No :

Swiss Port :

Q9BPZ2

Molecular weight :

29kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Nucleus Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.