Anti-RNLS Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

RNLS

Immunogen :

KLH conjugated synthetic peptide derived from human RNLS

Synonym :

C10orf59;Chromosome 10 open reading frame 59;FLJ11218;Hypothetical protein LOC55328;MAO C;Monoamine oxidase C;RENALASE;Renalase, FAD dependent amine oxidase;RNLS antibody;RNLS_HUMAN

Isotype :

IgG

Gene ID :

55328

Clone No :

Swiss Port :

Q5VYX0

Molecular weight :

35/38kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat Dog Pig Horse Rabbit

Application :

WB ELISA IHC-P IHC-F IF

Recommended dilution :

WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.

Subcellular location :

Secreted

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.