Anti-JPT1 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

JPT1

Immunogen :

A synthetic peptide of human JPT1

Synonym :

ARM2;HN1;HN1A

Isotype :

IgG

Gene ID :

51155

Clone No :

Swiss Port :

Q9UK76

Molecular weight :

11/16/20kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB

Recommended dilution :

WB 1:500-2000.

Subcellular location :

Nucleus Cell membrane

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.