Recombinant Human Cyclophilin B/PPIB/CYP-S1/CYPB/HEL-S-39/OI9/SCYLP

No :   P00899
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PRODUCT DESCRIPTION

Description :

Recombinant Human Peptidyl-prolyl cis-trans isomerase B is produced by our Mammalian expression system and the target gene encoding Asp34-Ala212 is expressed with a 6His tag at the C-terminus.

Formulation :

Lyophilized from a 0.2 米m filtered solution of PBS,pH 7.4.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin :

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Reconstitution :

Dissolve the lyophilized protein in distilled water.

Storage :

Lyophilized protein should be stored at < -20~C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7~C for 2-7 days.Aliquots of reconstituted samples are stable at < -20~C for 3 months.

Background :

Cyclophilin B (SCYLP, CyPB and peptidyl-prolyl cis-trans isomerase B) is a 24 kDa glycoprotein member of the B subfamily of the cyclophilin-type PPIase family of molecules. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones.
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