Anti-TIRAP Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TIRAP

Immunogen :

A synthetic peptide of TIRAP

Synonym :

BACTS1; Mal; MyD88-2; wyatt; TIR domain containing adaptor protein

Isotype :

IgG

Gene ID :

114609

Clone No :

Swiss Port :

P58753

Molecular weight :

24/25/28kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:100-300.

Subcellular location :

Cell membrane Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.