Anti-DCTN1 Polyclonal Antibody

No :   K110404P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

DCTN1

Immunogen :

Recombinant protein of human DCTN1

Synonym :

DAP-150;DP-150;P135

Isotype :

IgG

Gene ID :

1639

Clone No :

Swiss Port :

Q14203

Molecular weight :

127/137/142kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC 1:50-200.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20~C. Avoid freeze / thaw cycles.

Background :

Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation.
RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data