Anti-ITGB4 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ITGB4

Immunogen :

A synthetic peptide of human ITGB4

Synonym :

CD 104; CD104; CD104 antigen; gp150; Integrin beta 4 subunit; Integrin beta-4; ITB4_HUMAN; ITG B4; ITGB 4; Itgb4

Isotype :

IgG

Gene ID :

3691

Clone No :

Swiss Port :

P16144

Molecular weight :

107/194/195/201/202kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Cell membrane

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).