PRODUCT DESCRIPTION
Conjugation :
UnconjugationHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
IL33Immunogen :
Recombinant protein of human IL33Synonym :
C9orf26;DVS27;IL1F11;NF-HEV;NFEHEVIsotype :
IgGGene ID :
90865Clone No :
Swiss Port :
O95760Molecular weight :
26/31kDaPurification :
Affinity purificationReactivity :
HumanApplication :
IHCRecommended dilution :
IHC 1:50-200.Subcellular location :
Nucleus CytoplasmStorage :
Store at -20~C. Avoid freeze / thaw cycles.Background :
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.RELATED PRODUCTS
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REFERENCE LIBRARY
No data