PRODUCT DESCRIPTION
Conjugation :
UnconjugationHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
DTNBP1Immunogen :
Recombinant protein of human DTNBP1Synonym :
BLOC1S8;DBND;HPS7;My031;SDY;dysbindinIsotype :
IgGGene ID :
84062Clone No :
Swiss Port :
Q96EV8Molecular weight :
30/35/39kDaPurification :
Affinity purificationReactivity :
Human Mouse RatApplication :
WB IHCRecommended dilution :
WB 1:1000-3000. IHC 1:50-200.Subcellular location :
Cytoplasm NucleusStorage :
Store at -20~C. Avoid freeze / thaw cycles.Background :
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data