Anti-ARNT2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ARNT2

Immunogen :

Recombinant protein of human ARNT2

Synonym :

ARNT2;WEDAS;bHLHe1

Isotype :

IgG

Gene ID :

9915

Clone No :

Swiss Port :

Q9HBZ2

Molecular weight :

78/79kDa

Purification :

Octanoic acid-ammonium sulfate precipitation

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Nucleus Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.