Anti-IKZF4 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

IKZF4

Immunogen :

A synthetic peptide of human IKZF4

Synonym :

Eos;ZNFN1A4

Isotype :

IgG

Gene ID :

64375

Clone No :

Swiss Port :

Q9H2S9

Molecular weight :

60/64kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).