Anti-GNL3L Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

GNL3L

Immunogen :

A synthetic peptide of human GNL3L

Synonym :

Isotype :

IgG

Gene ID :

54552

Clone No :

Swiss Port :

Q9NVN8

Molecular weight :

66kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Predicted: Cow

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Nucleus Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.