Mouse ACV-A/Activin A ELISA KIT

Species :

Mouse

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

31.25pg/ml

Detection Range :

62.5-4,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum, plasma, Cell culture supernatant

Long Name :

Activin A

Synonyms :

ACV-A,Activin A

Background :

Activin A is two activin βA subunits and belongs to the TGF-β protein superfamily.[1]. Activin A is produced in the gonads, pituitary gland, placenta, and other organs. Activin A is more plentiful in the adipose tissue of obese, compared to lean persons.[2] Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation. Its action in wound repair and skin morphogenesis is through stimulation of keratinocytes and stromal cells in a dose-dependent manner.[3] Lack of activin during development results in neural developmental defects. Upregulation of Activin A drives pluripotent stem cells into a mesoendo dermal fate, and thus provides a useful tool for stem cell differentiation and organoid formation.[4] Activin A is overexpressed in many cancers. It was shown to promote tumorigenesis by hampering the adaptive anti-tumor immune response in melanoma.[27] Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts. Activin A promotes the proliferation of adipocyte progenitor cells, while inhibiting their differentiation into adipocytes.[2] Activin A also increases inflammatory cytokines in macrophages.[2] In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle.