Mouse Carboxypeptidase B1 ELISA KIT

Species :

Mouse

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

6.25pg/mL

Detection Range :

12.5-800pg/mL

Assay Length :

3.5h

Sample Type :

Serum, plasma, Cell culture supernatant

Long Name :

Carboxypeptidase B1

Synonyms :

0910001A18Rik ; 1810063F02Rik ; 2210008M23Rik ; AI504870 ；carboxypeptidase B1 (tissue)

Background :

Carboxypeptidase B1, also well known as pancreatic procarboxypeptidase B (PCPB), is a highly pancreas -specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitis and pancreatic graft rejection. As the prototype for those human exopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 37-aa mature chain. The secreted PCPB zymogen is converted to enzymatically active CPB1 by limited proteolysis by trypsin.