Anti-RIT1 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

RIT1

Immunogen :

KLH conjugated synthetic peptide derived from human RIT1

Synonym :

GTP binding protein Roc1; GTP-binding protein Rit1; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; RIT; RIT1; RIT1_HUMAN; ROC1.

Isotype :

IgG

Gene ID :

6016

Clone No :

Swiss Port :

Q92963

Molecular weight :

25kDa

Purification :

Affinity purification

Reactivity :

Predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep

Application :

Recommended dilution :

WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:50-200.

Subcellular location :

Cell membrane

Storage :

Shipped at 4⊥. Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.

Background :

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins.