PRODUCT DESCRIPTION
Species :
MouseAssay Type :
Solid Phase Sandwich ELISASensitivity :
8 pg/mlDetection Range :
15.6-1,000 pg/mlAssay Length :
3.5hSample Type :
Serum; Plasma; Cell culture supernatant.Long Name :
Chemokine (C-C motif) ligand 4Synonyms :
CCL4; ACT2; G-26; LAG1; HC21; MIP1b; MIP-1-beta; MIP1BMIP1-B; SCYA4; Chemokine C-C-Motif Ligand 4; Small Inducible Cytokine A4; Homologous To Mouse Mip-1bBackground :
CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.RELATED PRODUCTS
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REFERENCE LIBRARY
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