PRODUCT DESCRIPTION
Species :
MouseAssay Type :
Solid Phase Sandwich ELISASensitivity :
30 pg/mlDetection Range :
62.5-4,000 pg/mlAssay Length :
3.5hSample Type :
Serum; Plasma; Cell culture supernatant.Long Name :
OsteoprotegerinSynonyms :
TNFRSF11B; TNFRSF11-B; OCIF; OPG; PDB5; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor;TNF receptor superfamily member 11b;Background :
Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.RELATED PRODUCTS
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REFERENCE LIBRARY
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