Mouse OPG Elisa Kit

No :   SEKM-0121
Size :   
Quantity :   
PRODUCT DESCRIPTION

Species :

Mouse

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

30 pg/ml

Detection Range :

62.5-4,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Osteoprotegerin

Synonyms :

TNFRSF11B; TNFRSF11-B; OCIF; OPG; PDB5; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor;TNF receptor superfamily member 11b;

Background :

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.
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