Mouse TRANCE/TNFSF11/RANKL Elisa Kit

Species :

Mouse

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

30 pg/ml

Detection Range :

62.5-4,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

TNF-related Activation-induced Cytokine

Synonyms :

TNFSF11; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf; TNLG6B; TNF superfamily member 11

Background :

TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.