Rat IL-17F Elisa Kit

Species :

Rat

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

7 pg/ml

Detection Range :

31.2-2,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Interleukin 17F

Synonyms :

Cytokine ML-1; IL17F; IL-17F; IL-17F Interleukin-17F; IL24; IL-24; Interleukin 17F; Interleukin-24; ML-1; ML1 Interleukin-24

Background :

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.