Product Description

Species: Sheep
Assay Type: Solid Phase Sandwich ELISA
Sensitivity: 2 pg/ml
Detection Range: 12-800 pg/ml
Assay Length: 2-2.5h
Sample Type: Serum; Plasma; Cell culture supernatant.
Long Name: Interleukin 8
Synonyms: CXCL8; Chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine ligand 8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; IL8; Interleukin-8
Background: Interleukin-8 (IL-8), also known as CXCL8, is a chemokine that is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. IL-8 can form homodimers and heterodimers with CXCL4/PF4. Its bioactivity is regulated by proteolytic truncations, citrullination, and the decoy receptor DARC. IL-8 signals through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. IL-8 also binds to Serpin A1/alpha-1 Antitrypsin which prevents IL-8 interaction with CXCR1.
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REFERENCE LIBRARY

No:SEKS-0329
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