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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：79068
Application：Blocking Peptide of K110456P Antibody
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| Name | FTO Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q9C0B1 |
| Gene ID | 79068 |
| Interval Range | 190-240/505aa |
| Background | RNA demethylase that mediates oxidative demethylation of different RNA species， such as mRNAs， tRNAs and snRNAs， and acts as a regulator of fat mass， adipogenesis and energy homeostasis (PubMed:22002720， PubMed:26458103， PubMed:28002401， PubMed:30197295， PubMed:26457839， PubMed:25452335). Specifically demethylates N6-methyladenosine (m6A) RNA， the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720， PubMed:26458103， PubMed:30197295， PubMed:26457839， PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N6，2’-O-dimethyladenosine cap (m6A(m))， by demethylating the N6-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401， PubMed:30197295). Demethylation of m6A(m) in the 5’-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N1-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil， single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698， PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698， PubMed:20376003). Involved in the regulation of fat mass， adipogenesis and body weight， thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698， PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC， CEBPA， ASB2 and RARA， leading to promote their expression (PubMed:28017614， PubMed:29249359). |
| Application | Blocking Peptide of K110456P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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