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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：2268
Application：Blocking Peptide of K110457P Antibody
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| Name | FGR Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | P09769 |
| Gene ID | 2268 |
| Interval Range | 15-65/529aa |
| Background | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses， including neutrophil， monocyte， macrophage and mast cell functions， cytoskeleton remodeling in response to extracellular stimuli， phagocytosis， cell adhesion and migration. Promotes mast cell degranulation， release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins， such as MS4A2/FCER1B， FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2， and regulates actin cytoskeleton reorganization， cell spreading and adhesion. Depending on the context， activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling， phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling， normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells， leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG， and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL， CTTN， PIK3R1， PTK2/FAK1， PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK， but not unphosphorylated HCLS1. Together with CLNK， it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). |
| Application | Blocking Peptide of K110457P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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