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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：84446
Application：Blocking Peptide of K111090P Antibody
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| Name | BRSK1 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q8TDC3 |
| Gene ID | 84446 |
| Interval Range | 460-510/778aa |
| Background | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B， CDC25C， MAPT/TAU， RIMS1， TUBG1， TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1， acts as a key regulator of polarization of cortical neurons， probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in postmitotic neurons， leading to down-regulate WEE1 activity in polarized neurons. In neurons， localizes to synaptic vesicles and plays a role in neurotransmitter release， possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at ’Ser-131’， leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response， probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1， and inhibition of CDC25B and CDC25C. |
| Application | Blocking Peptide of K111090P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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