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My CartReactivity：Human,Rat,Mouse
Application：IHC,WB,IF
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：811
Host：Rabbit
Qty：
Size：
| Name | Anti-CALR Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:1000-3000. IHC 1:50-200. IF 1:50-200. |
| Target | CALR |
| Background | CALR,also named as grp60, ERp60, HACBP, CRP55, CRTC and Calregulin, belongs to the calreticulin family. It is a molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. CALR is a ER marker. It interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. CALR interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. The MW of CALR migrates aberrantly at 55 kDa by SDS-PAGE. Some study provided that it's a new possibility for CRT-mediated tumor immune prevention and treatment. |
| Swiss Prot | P27797 |
| Gene ID | 811 |
| Subcellular Location | Cytoplasm |
| Immunogen | Recombinant protein of human CALR |
| Public Immunogen Range | 1-393aa |
| Calculated MW | 48kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Rat Mouse |
| Application | WB IF IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with CALR antibody diluted at 1:2000;Lane: HepG2,293T,HL-60,HeLa,Kidney cancer,Mouse liver.
Immunohistochemistry of paraffin-embedded Human prostate cancer with CALR antibody diluted at 1:100.
Immunofluorescence analysis of SH-SY5Y cells using CALR antibody diluted at 1:100.
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PD-L1 Blockade Peptide-Modified Polymeric Nanoparticles for Oxygen-Independent-Based Hypoxic Tumor Photo/Thermodynamic Immunotherapy
Click to check >>Author：Xiaotong Gu, Bin Wu, Guoyan Feng, Zhengshengnan Chen, Fangli Ren, Xiangjun Chen, Wei Hong, Wenting Li
IF：4.9000
Publish_to：MOLECULAR PHARMACEUTICS
PMID：37427910
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