Gene Name |
MEK2(MAP2K2) |
Synonyms |
ERK activator kinase 2,FLJ26075,MAP kinase kinase 2,MAP2K2,MAPK/ERK kinase 2,MAPKK 2,MAPKK2,MEK 2,MEK2,MKK2,PRKMK2 |
English Name |
Recombinant human MEK2(MAP2K2) protein |
Full Name |
Mitogen-activated protein kinase 2 |
Chinese Name |
丝裂原活化蛋白激酶2 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P36507 |
Gene ID |
5605 |
Reactivity |
Human Mouse Rat (Dog Chicken) |
Molecular Weight |
44kDa |
Interval Range |
1-400aa |
Background |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.This kinase is known to play a critical role in mitogen growth factor signal transduction.It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome.The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.A pseudogene, which is located on chromosome 7, has been identified for this gene. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |