Gene Name |
casp1 |
Synonyms |
CASP 1,CASP1,Caspase 1,Caspase 1/p20/p10,Caspase1,ICE,IL 1 beta converting enzyme,IL 1BC,IL1BC,IL1BCE,Interleukin 1 beta convertase,p10,p20,P45 |
English Name |
Recombinant human casp1 protein |
Full Name |
caspase 1,apoptosis-related cysteine peptidase |
Chinese Name |
胱天蛋白酶1 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 2-7 days, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P29466 |
Gene ID |
834 |
Reactivity |
Human Mouse Rat (Zebrafish Horse Dog Pig Cat) |
Molecular Weight |
45kDa |
Interval Range |
1-404aa |
Background |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing.This gene has been shown to induce cell apoptosis and may function in various developmental stages.Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease.Alternative splicing results in transcript variants encoding distinct isoforms |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
No activity experimental data, to be verified. |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |