Gene Name |
RPSA |
English Name |
ribosomal protein SA |
Chinese Name |
核糖体蛋白SA |
Uniprot |
P08865 |
GeneID |
3921 |
Predicted Cross Reactivity |
Human Mouse Rat (Bovine Zebrafish Pig Sheep) |
氨基酸大小 |
33kDa |
表达氨基酸 |
1-295aa |
Background |
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes.They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.Many of the effects of laminin are mediated through interactions with cell surface receptors.These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins.This gene encodes a high-affinity, non-integrin family, laminin receptor 1.This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein.The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function.It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts.Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events.Two alternatively spliced transcript variants encoding the same protein have been found for this gene. |
Application |
Immunology research |
Source |
E.coli |
Purification |
NI-NTA affinity purification |
Formulation |
Lyophilized from a 0.2 μm filtered solution of Urea, Tris-HCl, PH8.0. |
Delivery Condition |
The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage |
Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution |
Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity |
Purity≥85% as determined by reducing SDS-PAGE. |
Bioactive |
Not tested. |
Tag information |
With a 6His tag at the N-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |