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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-ATXN1 Polyclonal Antibody
Chinese Name	共济失调蛋白1抗体
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Dilution Ratio	IHC 1:50-200.
Target	ATXN1
Synonyms	ATXN1;ATX1;D6S504E;SCA1;ataxin-1
Background	The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
Swiss Prot	P54253
Gene ID	6310
Subcellular Location	Cytoplasm Cell membrane Nucleus
Immunogen	A synthetic peptide of human ATXN1
Public Immunogen Range	695-745/815aa
Calculated MW	87kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
Storage	Store at -20℃. Avoid freeze/thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Human Rat Mouse
Application	IHC