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Anti-ARID5A Polyclonal Antibody

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Cat.No：K114851P-SAlexa Fluor 640 Solarbio

Reactivity：Mouse,Human

Storage：Store at -20℃. Avoid freeze / thaw cycles.

Host：Rabbit

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Product Information

Reactivity	Mouse,Human
Background	Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988).May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity).Can repress ESR1-mediated transcriptional activation;proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852).As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs;at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes
Subtype	IgG
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Host	Rabbit
Application	WB IHC

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Kindly reminder：Quick spin before use. If you have any questions, please contact us.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.