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My CartReactivity：Human,Rat,Mouse
Application：Cy5
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：54956
Purity：PARP16
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| Reactivity | Human,Rat,Mouse |
| Background | Intracellular mono-ADP-ribosyltransferase that plays a role in different processes， such as protein translation and unfolded protein response (UPR)， through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565， PubMed:23103912， PubMed:25043379， PubMed:34314702).Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits， such as RPL14 and RPS6， thereby inhibiting polysome assembly and mRNA loading (PubMed:34314702).Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 (PubMed:34314702).Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1， two important UPR effectors (PubMed:23103912).May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565).May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
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