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My Cart> Antibodies > Primary Antibodies > Anti-Phospho-EIF2S1(Ser51) Monoclonal AntibodySAlexa Fluor 350Reactivity：Mouse,Rat,Human
Application：SAlexa Fluor 350
Clone Type：Monoclonal Antibody
Storage：Store at -20℃.Avoid freeze/thaw cycles.
Gene ID：1965
Purity：Phospho-EIF2S1(Ser51)
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| Reactivity | Mouse,Rat,Human |
| Background | EIF2S1 is one subunit of the translation initiation factor EIF2 which catalyzes the first regulated step of protein synthesis initiation promoting the binding of the initiator tRNA to 40S ribosomal subunits.This complex binds to a 40S ribosomal subunit followed by mRNA binding to form a 43S preinitiation complex.Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.In order for eIF-2 to recycle and catalyze another round of initiation the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.This phosphorylation stabilizes the eIF2-GDP-eIF2B complex and inhibits the turnover of eIF2B.Induction of PKR by IFN and TNF induces potent phosphorylation of eIF2 at Ser51. |
| Subtype | IgG1 |
| Storage | Store at -20℃.Avoid freeze/thaw cycles. |
| Application | WB IF FCM ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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