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My Cart> Antibodies > Primary Antibodies > Anti-Phospho-AKT(Ser473) Monoclonal AntibodySAlexa Fluor 647Reactivity：Human,Rat,Mouse
Application：SAlexa Fluor 647
Clone Type：Monoclonal Antibody
Storage：Store at -20℃.Avoid freeze/thaw cycles.
Gene ID：207
Purity：Phospho-AKT(Ser473)
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| Reactivity | Human,Rat,Mouse |
| Background | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1， AKT2 and AKT3) called the AKT kinase， and which regulate many processes including metabolism， proliferation， cell survival， growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far， but for most of them， no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at ’Ser-50’ negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins， which is required for insulin-stimulated glucose transport (PubMed:11994271). |
| Subtype | IgG |
| Storage | Store at -20℃.Avoid freeze/thaw cycles. |
| Application | WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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