Anti-ADRA2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ADRA2

Immunogen :

A synthetic peptide of ADRA2

Synonym :

ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32; adrenoceptor alpha 2A

Isotype :

IgG

Gene ID :

150

Clone No :

Swiss Port :

P08913

Molecular weight :

51kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat Predicted:Cow Pig

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC 1:50-200.

Subcellular location :

Cell membrane

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.