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My Cart> Antibodies > Primary Antibodies > Anti-RIPK1 Polyclonal AntibodySAlexa Fluor 633Reactivity：Human
Application：SAlexa Fluor 633
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：8737
Host：Rabbit
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| Reactivity | Human |
| Background | Serine-threonine kinase which transduces inflammatory and cell-death signals following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-induc |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Host | Rabbit |
| Application | IHC IF |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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