Anti-GIT1 Polyclonal Antibody
Cat.No:K110897P-SAlexa Fluor 532 Solarbio
Reactivity:Human,Rat,Mouse
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Host:Rabbit
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Anti-GIT1 Polyclonal AntibodySAlexa Fluor 532Reactivity:Human,Rat,Mouse
Storage:Store at -20℃. Avoid freeze / thaw cycles.
Host:Rabbit
Qty:
Size:
Reactivity | Human,Rat,Mouse |
Background | Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5). |
Subtype | IgG |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Host | Rabbit |
Application | IHC |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder:Quick spin before use. If you have any questions, please contact us.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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