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My Cart> Antibodies > Primary Antibodies > Anti-USP15 Polyclonal AntibodySAlexa Fluor 680Reactivity：Mouse,Monkey,Human,Rat
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Host：Rabbit
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| Reactivity | Mouse,Monkey,Human,Rat |
| Background | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyze |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Host | Rabbit |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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