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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > DAPTCAS：208255-80-5
Molecular Formula：C23H26F2N2O4
Molecular Weight：432.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 208255-80-5 |
| Name | DAPT |
| Molecular Formula | C23H26F2N2O4 |
| Molecular Weight | 432.46 |
| Solubility | Soluble in DMSO ≥15mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00055267 |
| SMILES | FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1 |
| InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| InChI | InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 |
| PubChem CID | 5311272 |
| Target Point | Notch;γ-secretase;Autophagy;Apoptosis |
| Passage | Stem Cells;Neuronal Signaling;Autophagy;Apoptosis; |
| Background | DAPT is a potent gamma-secretase inhibitor that inhibits Notch 1 signaling and induces cell differentiation. It can also induce autophagy and apoptosis. It has neuroprotective activity. |
| Biological Activity | DAPT是 γ-分泌酶 (γ-secretase) 抑制剂，抑制总 Aβ 和 Aβ42 的 IC50 分别为 115 和 200 nM[5]。 |
| IC50 | 115nM(Aβ)，200nM(Aβ42)[5] |
| Data Literature Source | [1]. Dovey HF，et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81. [2]. Zhou JX，et al. γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361. [3]. Li S，et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33(6):1257-64. [4]. Tanimizu N，et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016 Jul;64(1):175-88. [5]. Michael T. Chang，et al. Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma. Yale University. January 2016. [6]. Majumder S，et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499. [7]. Yixin Tao，et al. β-catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis. J Mol Cell Biol. 2018 May 16. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway
Click to check >>Author：Shi J; Han G; Wang J; Han X; Zhao M; Duan X; Mi L;
IF：6.7800
Publish_to：Life Sci
PMID：32866517
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