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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > SB-431542CAS：301836-41-9
Molecular Formula：C22H16N4O3
Molecular Weight：384.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 301836-41-9 |
| Name | SB-431542 |
| Molecular Formula | C22H16N4O3 |
| Molecular Weight | 384.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD05865244 |
| SMILES | O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N |
| Target Point | TGF-β Receptor;ALK |
| Passage | TGF-beta/Smad |
| Background | SB-431542 is a potent and selective ALK5 inhibitor; also a transforming growth factor beta receptor (TGF-beta Receptor) inhibitor. |
| Biological Activity | SB-431542 是一种有效，选择性的 ALK5 抑制剂，IC50 值为 94 nM；同时也是转化生长因子 β 受体 (TGF-β Receptor) 抑制剂。[1-6] |
| IC50 | 94nM(ALK5)[2] |
| Data Literature Source | [1]. N. J. Laping，et al. Inhibition of Transforming Growth Factor (TGF)-β1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542. [2]. Inman GJ，et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4，ALK5，and ALK7. Mol Pharmacol，2002，62(1)，65-74. [3]. Halder SK，et al. A specific inhibitor of TGF-beta receptor kinase，SB-431542，as a potent antitumor agent for human cancers. Neoplasia，2005，7(5)，509-521. [4]. Matsuyama S，et al. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res，2003，63(22)，7791-7798. [5]. Sato M，et al. Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS One. 2015 May 18;10(5):e0126483. [6]. 'Ma J，et al. Growth differentiation factor 11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion. Brain Res Bull. 2018 Feb 9;139:38-47.' |
| Unit | Piece |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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