SB-431542_TGF-β Receptor_TGF-β/Smad_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	301836-41-9
English Name	SB-431542
Synonym	4-[4-(1;3-苯并二唑-5-基-5-(2-吡啶基-1H-咪唑-2-基]-苯酰胺水合物
Unit	Piece
Purity	≥98%
Molecular Formula	C₂₂H₁₆N₄O₃
Molecular Weight	384.39
Appearance	Solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD05865244
SMILES	O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
Description	SB-431542 is a potent and selective ALK5 inhibitor; also a transforming growth factor beta receptor (TGF-beta Receptor) inhibitor.
Target Point	TGF-β Receptor;ALK
Passage	TGF-beta/Smad
IC50	94 nM (ALK5)[2]
Data Literature Source	[1]. N. J. Laping, et al. Inhibition of Transforming Growth Factor (TGF)-β1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542. [2]. Inman GJ, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol, 2002, 62(1), 65-74. [3]. Halder SK, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 2005, 7(5), 509-521. [4]. Matsuyama S, et al. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res, 2003, 63(22), 7791-7798. [5]. Sato M, et al. Differential Proteome Analysis Identifies TGF-β-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS One. 2015 May 18;10(5):e0126483. [6]. "Ma J, et al. Growth differentiation factor 11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion. Brain Res Bull. 2018 Feb 9;139:38-47."
Specification	5mg 10mg 50mg