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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > NicotinamideCAS：98-92-0
Molecular Formula：C6H6N2O
Molecular Weight：122.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 98-92-0 |
| Name | Nicotinamide |
| Molecular Formula | C6H6N2O |
| Molecular Weight | 122.12 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 202-713-4 |
| MDL | MFCD00006395 |
| SMILES | O=C(C1=CC=CN=C1)N |
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) |
| PubChem CID | 936 |
| Target Point | Sirtuin |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Nicotinamide is a B3 vitamin that plays an important role in cellular physiology by promoting NAD+ redox homeostasis and providing NAD+ as a substrate for a class of enzymes that catalyze non-redox reactions. is an inhibitor of SIRT1. |
| Biological Activity | Nicotinamide是一种B3维生素，通过促进NAD +氧化还原稳态和提供NAD +作为催化非氧化还原反应的一类酶的底物，在细胞生理学中发挥重要作用。 烟酰胺是 SIRT1 的抑制剂。[1-4] |
| Data Literature Source | [1]. Bhansali SG， et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006; 16 (4) :173-80. [2]. Roslan J， et al. Quercetin ameliorates oxidative stress， inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24; 86:570-582 [3]. Fushima T， et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016 [4]. Suzuki E， et al. Protective effect of nicotinamide against poly (ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24; 86 (17-18) :676-82 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 10mM*1mL in Water 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Lin Y, et al. J Oral Microbiol. 2022 Mar 23;14(1):2056291.
Lin Y, et al. J Oral Microbiol. 2022 Mar 23;14(1):2056291.
Nicotinamide could reduce growth and cariogenic virulence of Streptococcus mutans
Click to check >>Author：Lin Y; Gong T; Ma Q; Jing M; Zheng T; Yan J; Chen
IF：4.5000
Publish_to：J Oral Microbiol
PMID：35341208
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