Forskolin_Inhibitors & Antagonists & Agonists_Small Molecule Compounds

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	66575-29-9
Chinese Name	佛司可林
English Name	Forskolin
Synonym	毛喉素;Coleonol;Colforsin;HL 362
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₂₂H₃₄O₇
Molecular Weight	410.5
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD00082317
EC	EINECS 266-410-9
InChIKey	OHCQJHSOBUTRHG-KGGHGJDLSA-N
InChI	InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
PubChem CID	47936
SMILES	O=C1[C@@]2(O)[C@]([C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@@]32C)(C)O[C@@](C)(C=C)C1
Description	Forskolin is a potent activator of adenylate cyclase and an inducer of intracellular cAMP formation. Forskolin activates the progesterone X receptor (PXR) and FXR. Forskolin also induces autophagy.
Target Point	Adenylate Cyclase(AC);FXR;PXR
Passage	GPCR & G Protein;Metabolic Enzyme&Protease
IC50	IC50: 41 nM (Adenylyl cyclase)；EC50: 0.5 μM (Adenylyl cyclase)[1]
Data Literature Source	[1]. Robbins JD, et al. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J Med Chem. 1996 Jul 5;39(14):2745-52. [2]. Rodriguez G, et al. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. J Biol Chem. 2013 Mar 8;288(10):7137-46. [3]. Matsumiya W, et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35. [4]. Ríos-Silva M, et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52.
Specification	5mg 10mM*1mL (in DMSO) 10mg 20mg