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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > ForskolinCAS：66575-29-9
Molecular Formula：C22H34O7
Molecular Weight：410.5
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 66575-29-9 |
| Name | Forskolin |
| Molecular Formula | C22H34O7 |
| Molecular Weight | 410.5 |
| Solubility | Soluble in DMSO ≥4mg/mL；Soluble in Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 266-410-9 |
| MDL | MFCD00082317 |
| SMILES | O=C1[C@@]2(O)[C@]([C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@@]32C)(C)O[C@@](C)(C=C)C1 |
| InChIKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| InChI | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
| PubChem CID | 47936 |
| Target Point | Adenylate Cyclase(AC);FXR;PXR |
| Passage | GPCR & G Protein;Metabolic Enzyme&Protease |
| Background | Forskolin is a potent activator of adenylate cyclase and an inducer of intracellular cAMP formation. Forskolin activates the progesterone X receptor (PXR) and FXR. Forskolin also induces autophagy. |
| Biological Activity | Forskolin 是一种有效的 腺苷酸环化酶 激活剂，结合到 I 型腺苷酸环化酶 IC50 为 41 nM，激活 I 型腺苷酸环化酶 EC50 为 0.5 μM[1]。 |
| IC50 | IC50: 41nM(Adenylyl cyclase);EC50: 0.5μM(Adenylyl cyclase)[1] |
| Data Literature Source | [1]. Robbins JD，et al. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J Med Chem. 1996 Jul 5;39(14):2745-52. [2]. Rodriguez G，et al. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. J Biol Chem. 2013 Mar 8;288(10):7137-46. [3]. Matsumiya W，et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35. [4]. Ríos-Silva M，et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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