CHIR-99021_GSK-3_PI3K/Akt/mTOR_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IC1680-5mg	Inquiry	Inquiry	Inquiry	Inquiry

CAS	252917-06-9
English Name	CHIR-99021
Synonym	CHIR-99021;CT99021;CHIR99021;CT-99021;
Unit	Piece
Purity	HPLC≥98%
Molecular Formula	C₂₂H₁₈Cl₂N₈
Molecular Weight	465.34
Appearance	White to yellow solid
Storage	Powder : 2-8℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO (Need ultrasonic)
MDL	MFCD11846251
EC	EINECS 809-015-4
InChIKey	AQGNHMOJWBZFQQ-UHFFFAOYSA-N
InChI	InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
PubChem CID	9956119
SMILES	N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
Description	It is a potent and selective GSK-3α/β inhibitor and a potent Wnt/β-catenin signaling pathway activator.
Target Point	GSK-3;Wnt/β-catenin
Passage	PI3K/Akt/mTOR;Stem Cells
IC50	GSK-3β:6.7 nM ; GSK-3α:10 nM [1-4]
Data Literature Source	[1]. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004. [3]. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273. [4]. Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.
Specification	5mg